What Causes Acromegaly?

Acromegaly is most often the result of a noncancerous tumor on the pituitary gland, also called a pituitary adenoma. The pituitary gland is a tiny gland located at the base of the brain. It produces many different hormones your body needs to function properly.

The Role of Hormones

There are 3 important hormones involved with acromegaly:

The tumor on the pituitary gland produces large amounts of GH, more than your body needs. This extra GH causes extra production of IGF-1. The increase of both of these hormones causes the signs and symptoms of acromegaly that you may be feeling and seeing in your own body.

Somatostatin is another hormone which slows the release of GH. With acromegaly, your body is unable to make enough somatostatin to keep up with the extra GH being released by the pituitary. The role of somatostatin has been important in the development of acromegaly treatment.